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عمومی::
مادهی خاکستری
Two infant magnetic resonance imaging (MRI) studies documented changes in gray matter (GM) and white matter (WM) tissue properties in prenatally SSRI-exposed infants (eg, altered fractional anisotropy of the thalamostriatal GM and
Based on prior animal studies, we hypothesized that prenatally SSRI-exposed infants would demonstrate altered GM morphology and WM connectivity within the corticolimbic circuit.
To test this, we used deformation-based GM morphometry and diffusion probabilistic WM tractography.
In this cohort study including 98 infants, significant gray matter volume expansion was noted in the amygdala and insula, as well as an increase in white matter structural connectivity between these same regions in selective serotonin reuptake inhibitor- exposed infants, compared with infants exposed to untreated prenatal maternal depression and healthy controls.
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